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Retinoid Receptor Pathway
- Molecular classification
- Signal Transduction Pathway, Nuclear Hormone Receptor Pathway
01
Overview
The retinoid receptor pathway is a crucial signaling mechanism mediated by retinoic acid (RA) and involving the Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs). It regulates gene expression, development, immunity, metabolism, and cellular differentiation through ligand-induced dimerization, DNA binding at RAREs, and recruitment of coactivators or corepressors.
- Other names
- Retinoic Acid Receptor PathwayVitamin A Signaling PathwayRAR/RXR Pathway
02
Mechanism of action
Ligand-induced dimerization with RAR/RXR, binding to RAREs, and modulation of gene transcription through recruitment of coactivators or corepressors.
03
Biological functions
Gene expression regulationEmbryonic developmentImmune response modulationMetabolic regulationCellular differentiationNeural developmentSynaptic plasticityTranscriptional regulation
04
Disease associations
Developmental disordersCancerImmune system diseasesMetabolic disorders
05
Safety considerations
TeratogenicityHypervitaminosis ASkin irritationMucous membrane drynessLiver toxicity
06
Interacting drugs
All-trans retinoic acid (ATRA)
5 more in the full profile.
07
Biomarkers
RAR expression levelsRXR expression levelsRARE-regulated gene expressionRA levelsCYP26 activity
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