Retinoid X receptor beta

Retinoid X receptor beta (RXR-β) is a member of the retinoid X receptor family of nuclear receptors. It forms heterodimers with other nuclear receptors, such as RARs, PPARs, VDR and TRs and regulates gene transcription upon binding to specific DNA response elements. The primary endogenous ligand is 9-cis-retinoic acid. RXR-β plays roles in energy metabolism, immune responses, development, and skin health. It is ubiquitously expressed. Variants or altered function/expression have been linked to granulomatosis with polyangiitis and vasculitis.

Other names

RXRβNR2B2nuclear receptor subfamily 2, group B, member 2nuclear receptor co-regulator 1RCoR-1

Ligand binding induces a conformational change, promoting corepressor dissociation and coactivator recruitment, leading to altered gene transcription.