Retinoid X Receptor Gamma (RXRγ)

Retinoid X receptor gamma (RXRγ), also known as NR2B3, is a member of the nuclear receptor superfamily that functions as a ligand-dependent transcription factor. It forms heterodimers with other nuclear receptors such as retinoic acid receptors (RARs), thyroid hormone receptors, vitamin D receptors, and peroxisome proliferator-activated receptors (PPARs). RXRγ is primarily expressed in the brain and muscle, and plays critical roles in energy metabolism, anti-inflammation, skin health, immune function, and vision maintenance. Genetic variants have been associated with metabolic disorders and potentially cancer progression. It is activated by 9-cis-retinoic acid.

Other names

NR2B3Nuclear receptor subfamily 2 group B member 3Retinoic acid receptor RXR-gammaRetinoid X receptor, gamma

Ligand-dependent transcription factor, forms heterodimers with other nuclear receptors to enhance DNA binding and transcriptional activity on respective response elements.