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Target intelligence / Profile preview
Retinol-binding protein (RBP)
- Target
- RBP
- Molecular classification
- Transporter, Lipocalin
01
Overview
Retinol-binding protein (RBP) is a lipocalin that mediates the transport of retinol from liver stores to peripheral tissues. It plays a crucial role in vitamin A metabolism and is essential for various biological processes, including vision and cell growth. The protein structure encapsulates retinol, allowing safe delivery within an aqueous environment. While RBP is not typically considered a therapeutic target, it is important for nutritional health and serves as a biomarker for visceral protein mass.
- Other names
- Plasma retinol-binding proteinRetinol transport protein
02
Mechanism of action
Not applicable as a therapeutic target, but it works by encapsulating retinol for transport
03
Biological functions
Transport of retinol from liver to peripheral tissuesregulation of retinoid metabolisminvolvement in signalingvisioncell growthdifferentiation
04
Disease associations
MalnutritionVitamin A deficiencyCertain kidney diseases (due to its role as a biomarker for visceral protein mass)
05
Safety considerations
None specifically associated with RBP itself, but malnutrition and vitamin A deficiency are significant health concerns
06
Interacting drugs
None specifically targeting RBP, but it interacts with retinoids and other hydrophobic molecules
07
Biomarkers
Used to assess visceral protein mass in nutrition-related health evaluations
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