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Target intelligence / Profile preview
Retinol binding protein 4 (RBP4)
- Target
- RBP4
- Molecular classification
- Lipocalin, Transport protein
01
Overview
Retinol binding protein 4 (RBP4) is a lipocalin that serves as the primary transport protein for retinol (vitamin A) in the bloodstream. Synthesized mainly in the liver and adipose tissue, it circulates bound to retinol and transthyretin (TTR). RBP4 delivers retinol to peripheral tissues via receptors like STRA6 and is implicated in glucose and lipid metabolism. Elevated levels are associated with insulin resistance and metabolic diseases.
- Other names
- Plasma Retinol-Binding ProteinPRBPRetinal-binding proteinPlasma retinal-binding protein
02
Mechanism of action
N/A
03
Biological functions
Vitamin A transportRetinol deliveryVitamin A homeostasisGlucose metabolism regulationLipid homeostasis regulation
04
Disease associations
Vision impairment/night blindnessInsulin resistanceType 2 diabetes mellitusCardiovascular diseaseMetabolic syndromeRenal failure
05
Safety considerations
Elevated levels associated with metabolic disordersDeficiency leads to vitamin A deficiency and associated complications
06
Biomarkers
Elevated RBP4 serum levels as indicator of insulin resistanceRBP4 levels as marker for metabolic diseasesRBP4 level in renal failure patients
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