Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Retinol-binding protein 5 (RBP5)
- Target
- RBP5
- Molecular classification
- Other (Lipocalin family, intracellular retinol-binding protein)
01
Overview
Retinol-binding protein 5 (RBP5) is a member of the intracellular lipocalin family of retinoid-binding proteins, primarily responsible for the intracellular transport of retinol (vitamin A alcohol) and fatty acids. It is highly expressed in the kidney and liver, and contributes to the cellular uptake, trafficking, and metabolism of retinol, supporting retinoid homeostasis by controlling substrate delivery to enzymes involved in vitamin A metabolism. Though its biological functions overlap with other cellular retinoid binding proteins (notably CRBP1 and CRBP2), RBP5’s physiological and pathophysiological roles, including its exact ligands and tissue-specific actions, remain less well characterized. Changes in expression of this protein may impact metabolic processes such as glucose and energy metabolism, and have been linked to disease susceptibility including some forms of cancer. Currently, there are no drugs reported to specifically target RBP5, nor is it a therapeutic target per se[1][2][4].
- Other names
- Cellular retinol-binding protein IIICRBP-IIICRBPIIICRBP3HRBPisoretinol binding protein 5, cellular
02
Biological functions
Intracellular transport of retinolfatty acid bindingfatty acid transportmodulation of retinoid metabolism
03
Disease associations
Other (Retinoid homeostasis, metabolic regulation, possible association with altered energy metabolism, glucose metabolism, and cancer progression in some tissues)
Beyond the preview
Go deeper on Retinol-binding protein 5 (RBP5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Retinol-binding protein 5 (RBP5).