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Target intelligence / Profile preview
Retinol dehydrogenase 10 (RDH10)
- Target
- RDH10
- Molecular classification
- Enzyme, Short-chain dehydrogenase/reductase (SDR) family
01
Overview
Retinol dehydrogenase 10 is an NADP-dependent oxidoreductase that catalyzes the conversion of all-trans-retinol into all-trans-retinal, a critical step in retinoic acid biosynthesis. Highly specific for all-trans-retinol, RDH10 is essential for embryogenesis, particularly for limb, craniofacial, and organ development, due to its role in producing retinoic acid. It is active mainly in the oxidation direction in vivo, and mutations can disrupt its function, leading to various congenital anomalies and retinal diseases[1][2][3][6].
- Other names
- SDR16C4short chain dehydrogenase/reductase family 16C member 4retinol dehydrogenase 10 (all-trans)short chain dehydrogenase/reductase family 16C, member 4
02
Mechanism of action
Not applicable; not a direct drug target as of current knowledge
03
Biological functions
Retinoid metabolismCatalysis of all-trans-retinol to all-trans-retinalRetinoic acid biosynthesisEmbryonic development (e.g., limb, craniofacial, organ development)Visual phototransduction
04
Disease associations
Congenital malformations (due to disruption of retinoic acid synthesis)Microphthalmia, syndromic 9Fundus albipunctatusOther developmental disorders relating to retinoic acid deficiency
05
Safety considerations
Potential developmental toxicity with inhibition (risk of birth defects)Disruption implicated in disorders of retinoid metabolism and visual cycle
06
Biomarkers
No established biomarkers for patient selection or efficacy monitoring specifically linked to RDH10; retinoic acid levels might infer functional output
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