Target intelligence / Profile preview

Retinoschisin 1 (RS1)

Target: RS1
Molecular classification: Extracellular matrix protein, Adhesion molecule

Overview

Retinoschisin 1 (RS1) is a secreted extracellular protein primarily expressed in the retina by photoreceptors and bipolar cells. It functions as an adhesion molecule crucial for maintaining the structural integrity and cytoarchitecture of the retina. RS1 forms a homo-oligomeric complex that mediates cell-cell interactions and influences ion channel activity. Mutations in RS1 cause X-linked juvenile retinoschisis (XLRS), a hereditary eye disease characterized by retinal splitting and progressive vision loss.

Other names: retinoschisinX-linked juvenile retinoschisis proteinXLRS1XLRS1_HUMAN

Biological functions

Cell-cell adhesionMaintenance of retinal structureModulation of ion channelsRegulation of fluid balance

Disease associations

X-linked juvenile retinoschisis

Safety considerations

Potential immunogenicity of gene therapyLong-term efficacy of gene therapy uncertain

Beyond the preview

Go deeper on Retinoschisin 1 (RS1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Retinoschisin 1 (RS1).

Explore the full profile