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Target intelligence / Profile preview
Retrograde Golgi transport protein RGP1 homolog (RGP1)
- Target
- RGP1
- Molecular classification
- Other (GEF complex partner/regulatory cofactor), Protein complex subunit (component of the Ric1-Rgp1 complex)
01
Overview
Retrograde Golgi transport protein RGP1 homolog (RGP1) is a regulatory subunit of the Ric1-Rgp1 complex, which acts as a guanine nucleotide exchange factor (GEF) specifically for the Rab6A GTPase, a master regulator of Golgi and post-Golgi trafficking. Rab6A, when activated (GTP-bound), is necessary for proper vesicular transport, Golgi apparatus organization, and retrograde trafficking of select receptors (such as mannose 6-phosphate receptors) from endosomes to the Golgi. Ric1 and Rgp1 must act together to facilitate the nucleotide exchange on Rab6A, promoting the active GTP-bound form necessary for these trafficking events. The Ric1-Rgp1 complex structure is distinct from other Rab GEFs, with Ric1 containing β-propeller and α-solenoid domains, and Rgp1 containing an arrestin-like domain critical for Golgi localization and interaction with Rab6A.
- Other names
- RGP1 partner of RAB6A GEF complexRAB6A-GEF complex partner protein 2KIAA0258Retrograde Golgi transport protein RGP1 homologRGP1 homologRAB6A GEF complex partner 1
02
Mechanism of action
Not applicable (no drugs directly targeting this protein)
03
Biological functions
Membrane traffickingRegulation of guanine nucleotide exchange on Rab6AGolgi homeostasisProtein transport/retrograde trafficking
04
Disease associations
Other (no established direct role in major diseases as a primary or therapeutic target; defects might impact general trafficking with possible implications in cellular or developmental disorders, but not strongly linked to specific diseases in current literature)
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