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Target intelligence / Profile preview
Retrotransposon Gag-like protein 6 (RTL6)
- Target
- RTL6
- Molecular classification
- Other
01
Overview
Retrotransposon Gag-like protein 6 (RTL6) is a human protein encoded by the RTL6 gene, which is a member of the Mart family derived from ancient retrotransposons. RTL6 has a predicted leucine zipper motif that may mediate nucleic acid binding, and is primarily localized to the nucleus and cytosol. It is expressed at high levels in many tissues and throughout development. Although RTL6 shows interactions with various proteins, and its expression can be downregulated in certain cancer cells upon chemotherapy treatment, its biological function and disease relevance remain poorly characterized. There are no known therapeutic drugs targeting RTL6, nor established biomarkers or safety concerns related to this target[1][3][6].
- Other names
- LDOC1LMAR6MART6SIRH3dJ1033E15.2Leucine zipper protein down-regulated in cancer cells-likeMammalian retrotransposon-derived protein 6Protein LDOC1LSushi-Ichi retrotransposon homolog 3LDOC1 likeleucine zipper down-regulated in cancer 1 likeMar6Mart6
02
Biological functions
UnknownPossible nucleic acid binding
03
Disease associations
Other (association with Temple syndrome and altered expression in cancer cells, but function not established)
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