REV1 homolog pseudogene

The **REV1 homolog pseudogene** (ENSG00000262000, also known as AC120024.2) is classified in the human genome as a pseudogene, meaning it is a DNA sequence similar to a gene but generally nonfunctional due to disabling mutations or lack of regulatory elements required for proper expression. Specifically, it is described as a "REV1 homolog (S. cerevisiae) (REV1) pseudogene," meaning it shares sequence similarity with the functional yeast REV1 gene but does not encode a functional protein in humans[1][3]. Pseudogenes predominantly do not perform the biological roles typical of protein-coding genes and are not considered therapeutic targets such as receptors, enzymes, transporters, or transcription factors[2][4]. There is no evidence supporting the use of this pseudogene in drug targeting, biomarker development, or human disease association as a functional molecule. Pseudogenes are generally regarded as non-functional sequences, often the result of duplication or retrotransposition events, and may not be transcribed or translated[2][6]. Occasionally, pseudogenes can have regulatory roles or be transcribed in specific contexts, but no such evidence was found for ENSG00000262000[4]. There is no known link to breast cancer or other disease relevance for drug targeting, and it is not listed as a functional or actionable gene in the relevant biomedical databases[1][3]. Because this is not a protein-coding or functional RNA gene, this entry is not suitable as a therapeutic target or biomarker, and lists for drugs, mechanisms, or safety concerns are not applicable. There is something incorrect with this target in a therapeutic/research setting: The entry is a pseudogene and therefore not a valid molecular target[1][3]. No canonical abbreviation or any evidence of use as a biomedical target was found. If you need further information about the functional REV1 gene (which encodes a DNA repair protein in humans), a separate, functional gene entry should be referenced.

Other names

AC120024.2ENSG00000262000