RevCAR peptide epitope

The RevCAR peptide epitope is a synthetic short peptide domain incorporated into the extracellular portion of engineered T cells (or NK cells) in the RevCAR system. This peptide serves as a unique, orthogonal recognition site for adapter molecules known as RevCAR target modules (RevTMs), which are bispecific antibodies that simultaneously bind this synthetic epitope and a tumor-associated antigen (e.g., fibroblast growth factor-inducible 14 or PD-L1). This system allows researchers and clinicians to control activation of the engineered immune cells in a stimulus-dependent manner, enhancing therapeutic safety and modularity. The peptide’s function is not derived from endogenous biology but is a tool for precise immune cell redirection in adoptive cell therapy platforms[3][5][7].

Other names

RevCAR epitopeE5B9E7B6synthetic peptide epitope (RevCAR)

Enables switchable, reversible activation of engineered immune cells when used with bispecific RevCAR target modules (RevTMs)