Target intelligence / Profile preview

Reverse Transcriptase (RT)

Target: RT
Molecular classification: Enzyme, Polymerase

Overview

Reverse transcriptase (RT) is an enzyme that catalyzes the synthesis of complementary DNA (cDNA) from an RNA template. This activity is essential for the replication of retroviruses such as HIV and hepatitis B, as well as for the proliferation of retrotransposons within host genomes. RTs are also found in eukaryotic cells, where they play a role in telomere maintenance via telomerase. Inhibitors targeting reverse transcriptases form key components of antiretroviral therapies against diseases like HIV/AIDS.

Mechanism of action

Inhibition of reverse transcriptase activity, blocking cDNA synthesis and viral replication.

Biological functions

DNA synthesisRNA degradationRetroviral replicationRetrotransposon mobilityTelomere maintenance

Disease associations

Infection

Interacting drugs

Nucleoside/nucleotide analogues

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