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Target intelligence / Profile preview
Hepatitis B Virus Polymerase/Reverse Transcriptase (HBV Pol/RT)
- Target
- HBV Pol/RT
- Molecular classification
- Enzyme, Reverse Transcriptase, Polymerase
01
Overview
The hepatitis B virus (HBV) polymerase, also known as reverse transcriptase (RT), is a multifunctional viral enzyme essential for HBV replication. It catalyzes the conversion of pregenomic RNA (pgRNA) into partially double-stranded DNA within the viral capsid. Current therapies target the RT activity, but ongoing research aims to develop inhibitors against additional functional domains like the RNase H domain to overcome resistance and improve treatment outcomes. The enzyme contains Terminal Protein, Spacer, RT, and RNase H domains.
- Other names
- Hepatitis B virus polymeraseP proteinReverse transcriptase
02
Mechanism of action
Nucleos(t)ide analogs that inhibit viral DNA chain elongation by targeting the RT domain.
03
Biological functions
Viral genome replicationReverse transcriptionDNA synthesisRNA degradationProtein primingVirion assembly
04
Disease associations
InfectionHepatitis BLiver cancer
05
Safety considerations
Drug resistanceLimited efficacy (viral suppression, not cure)Adverse effects associated with nucleos(t)ide analogsReactivation of HBV upon drug cessation
06
Interacting drugs
Entecavir
4 more in the full profile.
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