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Reverse transcriptase of human immunodeficiency virus type 1 (HIV‑1 RT)

Target: HIV‑1 RT
Molecular classification: Enzyme

Overview

HIV-1 reverse transcriptase (RT) is a multifunctional enzyme essential for the replication of the human immunodeficiency virus type 1 (HIV-1). It catalyzes the conversion of the viral single-stranded RNA genome into double-stranded DNA, which is then integrated into the host cell genome. This process, known as reverse transcription, is a hallmark of retroviral replication and is critical for viral propagation.

Mechanism of action

Inhibition of reverse transcriptase activity (DNA polymerase and/or RNase H)

Biological functions

Reverse transcriptionDNA synthesisRNA degradation

Disease associations

Infection

Safety considerations

Drug resistance due to mutations in RT

Interacting drugs

NRTIs

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