Reverse transcription (HIV)

Reverse transcription in HIV refers to the process by which the virus converts its single-stranded RNA genome into double-stranded DNA. This step is essential for viral replication and integration into the host genome. The enzyme responsible for this process is called reverse transcriptase (RT), a hallmark of all retroviruses, including HIV-1. Inhibiting reverse transcription blocks production of proviral DNA, preventing establishment or maintenance of chronic infection. This makes it one of the primary intervention points in current combination therapies against HIV/AIDS.

Inhibition of reverse transcriptase activity, preventing viral DNA synthesis and integration into the host genome.