REXO4, RNA exonuclease 4 homolog (S. cerevisiae) (REXO4)

REXO4, also known as RNA exonuclease 4 homolog (S. cerevisiae), is a gene encoding a 3'-5' exonuclease involved in nucleic acid metabolism, particularly contributing to DNA repair and transcriptional regulation[4][6][7]. REXO4 is found in the nucleolus and nuclear specks and shows DNA binding and nuclease activity[4]. While REXO4 is a protein-coding gene, the entry "REX4, RNA exonuclease 4 homolog pseudogene" (ENSG00000259696, LOC400347) refers to a pseudogene and not to the functional REXO4 protein[4][6][7]. The functional REXO4 (not the pseudogene) has been implicated as an oncogenic factor in hepatocellular carcinoma where it is upregulated and is correlated with poor prognosis, increased proliferation, migration, and invasion of liver cancer cells[1]. It has also been linked to inflammatory and neurological conditions[1]. No drugs or specific mechanism-based therapies target REXO4 directly, nor are there established safety or druggability data for it. Note: The entry you provided (ENSG00000259696; LOC400347) describes a **pseudogene** homologous to REXO4, not an active target. Functional data relates to the protein-coding REXO4 gene (e.g., ENSG00000148300). Pseudogenes do not encode active proteins and are generally not considered therapeutic targets. This entry is **not a correct or actionable therapeutic target**.

Other names

Exonuclease XPMC2XPMC2HPrevents mitotic catastrophe 2 protein homologREX4, RNA exonuclease 4 homolog pseudogeneREX4, RNA exonuclease 4 homolog (S. cerevisiae) pseudogeneLOC400347PMC2