Rhabdoid tumor deletion region gene 1 pseudogene

ENSG00000278655 is annotated as a pseudogene designated "rhabdoid tumor deletion region gene 1 pseudogene." Pseudogenes are gene sequences that resemble protein-coding genes but contain mutations (such as frameshifts or premature stop codons) that prevent them from producing functional proteins[1][5]. Typically, pseudogenes do not have biological function, though some may be transcribed and play regulatory roles, but there is no clinical or experimental evidence suggesting that this particular pseudogene functions as a therapeutic target or biomarker[1][5][3]. The actual gene of clinical and biological importance for rhabdoid tumors is **SMARCB1** (also known as INI1), which is a tumor suppressor and central to the biology of rhabdoid tumors[4][6], but this is distinct from the pseudogene described by ENSG00000278655. Key points: - *Pseudogenes* such as ENSG00000278655 frequently complicate sequencing analysis and should not be mistaken for their functional parent genes in molecular diagnostics[3][5]. - There is no reported role for this specific pseudogene in disease, drug interaction, or patient stratification. - The clinical and research relevance in rhabdoid tumors relates to loss-of-function or mutation of **SMARCB1**, not this pseudogene[2][4][6]. If you intended to refer to the functional protein-coding gene associated with rhabdoid tumors, it should be "SMARCB1" (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1)[4][6]. This target, as specified by ENSG00000278655, is not a relevant therapeutic or diagnostic target.