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Target intelligence / Profile preview
RhD Antigen (RhD)
- Target
- RhD
- Molecular classification
- Transmembrane multipass protein, Antigen
01
Overview
The RhD antigen is a highly immunogenic protein found on the surface of red blood cells. Its presence or absence determines whether an individual is classified as RhD positive or RhD negative. While its precise physiological function is not fully understood, it may play a role in gas transport across the red cell membrane. Its primary clinical significance lies in its role in hemolytic disease of the fetus and newborn (HDFN) due to maternal anti-D antibodies.
- Other names
- RHDCD240Dcluster of differentiation 240DHDFNRH
02
Biological functions
Potential membrane transporter for gasesErythrocyte structural component
03
Disease associations
Hemolytic disease of fetus/newborn (HDFN)
04
Safety considerations
Alloimmunization leading to anti-D antibody formationHemolytic transfusion reactionsHemolytic disease of fetus/newborn (HDFN)
05
Biomarkers
Presence/absence of RhD antigen on red blood cells
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