Target intelligence / Profile preview

Rhesus D Antigen (RhD)

Target: RhD
Molecular classification: Transmembrane multipass protein, Blood group antigen

Overview

The Rhesus D antigen (RhD) is a protein molecule found on the surface of red blood cells. Its presence or absence determines whether an individual is classified as RhD positive or RhD negative, which is a key component of the ABO/Rh blood group system. It plays a crucial role in transfusion medicine and hemolytic disease of the fetus and newborn (HDFN). While its precise physiological function remains unclear, evidence suggests that together with associated proteins like RHAG, it may play roles in ammonium or carbon dioxide transport across erythrocyte membranes.

Biological functions

Possibly involved in gas transport (ammonium or carbon dioxide)

Disease associations

Hemolytic disease of the fetus and newborn (HDFN)Transfusion reactions

Safety considerations

AlloimmunizationHemolytic transfusion reactionsHemolytic disease of the fetus and newborn (HDFN)

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