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Target intelligence / Profile preview
Rhesus factor type D antigen (RhD)
- Target
- RhD
- Molecular classification
- Transmembrane protein, Multipass protein
01
Overview
The Rhesus factor type D antigen (RhD antigen) is a protein found on the surface of red blood cells. Its presence or absence determines Rh-positive or Rh-negative blood type. It is highly immunogenic, and exposure of Rh-negative individuals to RhD-positive blood can lead to the production of anti-D antibodies, resulting in transfusion reactions or hemolytic disease of the fetus and newborn (HDFN). While its precise physiological function is uncertain, it is structurally related to ammonia transporters and may be involved in transporting ammonium or carbon dioxide.
- Other names
- RhD antigenCD240DRh factor type D
02
Mechanism of action
Rh immunoglobulin (RhoGAM) binds to RhD-positive fetal red blood cells in the maternal circulation, preventing the mother from producing anti-D antibodies.
03
Biological functions
Possibly involved in CO2/ammonia transportRed blood cell structure and integrity
04
Disease associations
Hemolytic disease of the fetus and newborn (HDFN)Transfusion reactions
05
Safety considerations
Alloimmunization to RhD antigenHemolytic transfusion reactionsHemolytic disease of the fetus and newborn (HDFN)
06
Interacting drugs
Rh immunoglobulin (RhoGAM)
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