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Target intelligence / Profile preview
Rhinovirus 3C Protease (HRV 3Cpro)
- Target
- HRV 3Cpro
- Molecular classification
- Enzyme, Cysteine protease
01
Overview
Rhinovirus 3C protease (HRV 3Cpro) is a cysteine protease essential for viral replication in human rhinoviruses, the primary cause of the common cold. It cleaves the viral polyprotein to produce mature viral proteins and antagonizes host antiviral immunity. It is a validated drug target, with inhibitors like rupintrivir showing broad-spectrum antiviral activity.
- Other names
- 3C ProteaseHRV 3C protease
02
Mechanism of action
Irreversible inhibition of the active site cysteine residue of HRV 3C protease
03
Biological functions
Viral polyprotein cleavageViral replicationAntagonism of host immunity
04
Disease associations
Infection
05
Interacting drugs
Rupintrivir
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