Target intelligence / Profile preview

Rhinovirus 3C Protease (HRV 3Cpro)

Target: HRV 3Cpro
Molecular classification: Enzyme, Cysteine protease

Overview

Rhinovirus 3C protease (HRV 3Cpro) is a cysteine protease essential for viral replication in human rhinoviruses, the primary cause of the common cold. It cleaves the viral polyprotein to produce mature viral proteins and antagonizes host antiviral immunity. It is a validated drug target, with inhibitors like rupintrivir showing broad-spectrum antiviral activity.

Other names: 3C ProteaseHRV 3C protease

Mechanism of action

Irreversible inhibition of the active site cysteine residue of HRV 3C protease

Biological functions

Viral polyprotein cleavageViral replicationAntagonism of host immunity

Disease associations

Infection

Interacting drugs

Rupintrivir

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