Target intelligence / Profile preview

Rhinovirus Capsid Protein VP1 (VP1)

Target: VP1
Molecular classification: Viral structural protein, Capsid protein

Overview

Rhinovirus capsid protein VP1 plays essential roles both structurally—as part of an organized shell protecting viral RNA—and functionally—in determining host range via specific interactions with cellular receptors. Its dynamic regions contribute both to immune evasion/recognition and enable conformational changes required during infection. As such it remains a prime target for antiviral development efforts against common cold viruses caused by HRVs.

Mechanism of action

Inhibits virus uncoating by stabilizing capsid conformation

Biological functions

Genome protectionCell attachmentCell entryReceptor binding

Disease associations

Infection

Safety considerations

Sequence variation correlates with drug susceptibility

Interacting drugs

Pleconaril

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