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Target intelligence / Profile preview
Rho-associated coiled-coil containing protein kinase 1 (ROCK1)
- Target
- ROCK1
- Molecular classification
- Serine/threonine kinase, AGC family of kinases
01
Overview
Rho-associated coiled-coil containing protein kinase 1 (ROCK1) is a serine/threonine kinase and a major downstream effector of the small GTPase RhoA. It plays a central role in regulating the actin cytoskeleton, cell shape, motility, contraction, proliferation, apoptosis, and other cellular processes. Overexpression or dysregulation of ROCK1 has been linked to various diseases, including glaucoma, cancer, cardiovascular disease, and inflammatory conditions. ROCK inhibitors are under investigation as potential therapeutic agents.
- Other names
- ROKβP160ROCKLet-502 kinaseRok
02
Mechanism of action
Modulation of cytoskeletal dynamics, cell survival, apoptosis, inflammation, and tissue remodeling.
03
Biological functions
Actomyosin contractility regulationStress fiber formationFocal adhesion formationCell polarity regulationCell migrationApoptosisCell proliferationCell differentiationSmooth muscle contraction
04
Disease associations
GlaucomaCancerCardiovascular diseaseInflammatory conditionsKidney disease
05
Interacting drugs
ROCK inhibitors (experimental)
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