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Target intelligence / Profile preview
Rho-associated Coiled-coil Containing Protein Kinase (ROCK)
- Target
- ROCK
- Molecular classification
- Enzyme, AGC serine/threonine kinase, Protein Kinase
01
Overview
Rho-associated coiled-coil containing protein kinases (ROCKs) are serine/threonine kinases that play a central role in regulating the actin cytoskeleton, cell shape, and movement. They are major downstream effectors of the small GTPase RhoA and belong to the AGC family of protein kinases. There are two main isoforms in mammals: ROCK1 and ROCK2. Dysregulation or abnormal activation of ROCK has been implicated in several diseases, making it an attractive therapeutic target.
- Other names
- Rho-associated kinasep160ROCKROCK1ROCK IROKβROCK2ROCK IIROKα
02
Mechanism of action
Kinase inhibition
03
Biological functions
Actomyosin contractilityCell contractionCell migrationStress fiber formationFocal adhesion assemblyApoptosisSurvival signalingCytoskeletal regulationCell proliferation
04
Disease associations
Cardiovascular diseaseHypertensionMyocardial hypertrophyCerebral ischemiaAtherosclerosisGlaucomaCancerFibrosis
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