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Target intelligence / Profile preview
Rho-associated coiled-coil containing protein kinase 2 (None)
- Target
- None
- Molecular classification
- Enzyme, AGC Ser/Thr Kinase
01
Overview
Rho-associated coiled-coil containing protein kinase 2 (ROCK2) is a serine/threonine protein kinase that plays a central role in regulating the actin cytoskeleton, cell polarity, and smooth muscle contraction. It is one of two mammalian isoforms of Rho-associated kinases and acts as a major downstream effector for small GTPase RhoA, regulating several cellular processes including cytokinesis, smooth muscle contraction, and cell migration. ROCK2 is implicated in cardiovascular diseases such as hypertension and atherosclerosis.
- Other names
- Rho kinase IIp150 ROK-alphap164 ROCK-IIrho-associated protein kinase 2ROKalphaRockIIm
02
Mechanism of action
Inhibition of ROCK2 leading to reduced myosin light chain (MLC) phosphorylation and decreased actomyosin contractility.
03
Biological functions
Actin cytoskeleton regulationSmooth muscle contractionCell migrationApoptosisCell proliferationGene expression modulationCytokinesisCell adhesionSurvival
04
Disease associations
Cardiovascular diseaseHypertensionMyocardial hypertrophyCerebral ischemiaAtherosclerosis
05
Interacting drugs
Fasudil
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