Rho family GTPase 1 (RND1)

Rho family GTPase 1 (RND1) is a small (~21 kDa) signaling GTPase protein, encoded by the RND1 gene and belonging to the Rho family subgroup known as Rnd[1][3]. Unlike most GTPases, RND1 lacks intrinsic GTPase activity, constitutively binds GTP, and does not cycle between active/inactive forms in the standard manner[3][4]. RND1 is chiefly involved in regulating actin cytoskeleton organization and cell structure in response to extracellular signals[1][3][4]. In neurons, it participates in extending neurites and affects microtubule dynamics[2][3]. The protein interacts with several signaling effectors, including stathmin2 (neuronal growth), GRB7, PLXNB1, PDE6D, ARHGAP5, and UBXD5[1]. Disruption of its function or aberrant signaling via RND1 and related Rho GTPases has been implicated in cancer progression and developmental disorders[2][3]. The lack of intrinsic GTPase activity distinguishes RND1 from many classical Rho proteins[4].

Other names

RND1Rho-related GTP-binding protein Rho6RHO6ARHSRHOSRho family GTPase 1ras homolog gene family member SRho6

For theoretical drugs or tool compounds: Inhibition or modulation of GTPase activity; Disruption or enhancement of actin cytoskeleton organization; Affecting downstream effectors (e.g., stathmin2, microtubule-regulating proteins).