RHO family interacting cell polarization regulator 2 (RIPOR2)

RHO family interacting cell polarization regulator 2 (RIPOR2) is an adaptor and inhibitor protein that directly binds RHOA GTPase and suppresses its activity, thus playing a key role in cell migration, polarization, and cytoskeletal organization[1][3]. It is essential for several biological processes: it regulates T cell and neutrophil migration and polarization via RHOA inhibition, acts as a negative regulator of cell proliferation, and influences skeletal muscle cell differentiation and myoblast fusion[1][3]. In the auditory system, RIPOR2 is necessary for the development and maintenance of hair cell stereocilia; its loss causes non-syndromic hereditary deafness due to defects in hair cell bundle structure[3][4]. RIPOR2 activity is tightly regulated by upstream kinases and it integrates signals for immune cell migration, myogenesis, and autophagy in a context-dependent manner[1][3]. No direct therapeutic agents targeting RIPOR2 are currently known; however, its genetic variants serve as biomarkers in the diagnosis of hereditary deafness syndromes[3][4].

Other names

C6orf32DIFF48FAM65BKIAA0386PL48MYONAPDFNA21DFNB104DIFF40family with sequence similarity 65 member Bmyogenesis-related and NCAM-associated protein homologprotein FAM65B