Rho GDP dissociation inhibitor alpha (ARHGDIA)

Rho GDP dissociation inhibitor alpha (ARHGDIA) is a cytosolic regulator that maintains members of the Rho GTPase family—including CDC42, RAC1, and RHOA—in their inactive, GDP-bound states by preventing GDP dissociation and subsequent GTP binding. ARHGDIA extracts Rho GTPases from membranes into the cytosol, regulates their stability, protects them from degradation, and contributes to the proper distribution and recycling of the active and inactive forms. Through modulation of Rho GTPase signaling, ARHGDIA plays an essential role in cell motility, migration, cytoskeletal dynamics, and cellular homeostasis. Mutations or changes in ARHGDIA expression are associated with hereditary nephrotic syndromes and cancer cell migration and invasion.

Other names

Rho GDP-dissociation inhibitor 1GDIA1Rho GDI 1RHOGDIRho-GDI alphaRHOGDI-1HEL-S-47eNPHS8GDP-dissociation inhibitorAplysia Ras-related 1Epididymis secretory sperm binding protein Li 47e

siRNA/shRNA-mediated gene knockdown (experimental); Antibody inhibition or detection in research applications; (In principle) Small molecules or peptides inhibiting GDI activity or Rho GTPase interaction, though not clinically validated.