Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Rho GTP-binding Protein (Rho GTPase)
- Target
- Rho GTPase
- Molecular classification
- Ras superfamily, Small GTPase
01
Overview
Rho GTPases are a subfamily of the Ras superfamily of small GTPases that act as molecular switches cycling between an inactive GDP-bound state and an active GTP-bound state. They regulate actin cytoskeletal organization, cell migration, adhesion, morphology, cell cycle progression, secretion, pinocytosis/endocytosis, transcriptional activation, and DNA synthesis initiation. Dysregulation is implicated in cancer, making them potential anti-cancer drug targets.
- Other names
- RhoARhoBRhoCRac1Cdc42
02
Mechanism of action
Inhibition of Rho GTPase activity; disruption of downstream signaling pathways
03
Biological functions
Actin cytoskeletal organizationCell migrationCell adhesionCell morphologyCell cycle progressionSecretionPinocytosis/endocytosisTranscriptional activationDNA synthesis initiation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to involvement in multiple cellular processesDevelopment of resistance
Beyond the preview
Go deeper on Rho GTP-binding Protein (Rho GTPase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Rho GTP-binding Protein (Rho GTPase).