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Rho GTPase-activating protein 19 (ARHGAP19)
- Target
- ARHGAP19
- Molecular classification
- Enzyme (specifically, GTPase-activating protein), Other (regulator of small GTPases)
01
Overview
Rho GTPase-activating protein 19 (ARHGAP19) is an enzyme encoded by the ARHGAP19 gene in humans and is a member of the RhoGAP family[2][6]. ARHGAP19 acts as a GTPase activator for Rho-type GTPases, promoting the conversion from the active (GTP-bound) to the inactive (GDP-bound) state, thus serving as a negative regulator of Rho GTPase signaling[2][7]. Rho GTPases and their regulatory proteins play essential roles in the control of cytoskeletal organization, cell morphology, cellular migration, proliferation, and differentiation[1][2]. ARHGAP19 has been shown to influence epithelial morphogenesis and cytoskeleton remodeling during processes such as the establishment of uterine receptivity[1]. Although it is linked to pathways involved in cell cycle control and signal transduction, and its dysregulation may be associated with cancer, ARHGAP19 itself is not currently established as a direct therapeutic target or known receptor for any approved drugs[2][6][7].
- Other names
- Rho GTPase-activating protein 19ARHGAP19FLJ00194MGC14258Rho-type GTPase-activating protein 19putative RhoGAP protein4933411B03RIKAI120128AW546831mFLJ00368
02
Biological functions
Regulation of Rho GTPasesCytoskeleton organizationCell migrationCell proliferationCell differentiationActin remodelingG1 cell cycle progression
03
Disease associations
Cancer (e.g., endometrial adenosquamous carcinoma)Febrile seizures, familial 6 (noted as an association, not a confirmed causal role)
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