Rho GTPase activating protein 20 pseudogene

The Rho GTPase activating protein 20 pseudogene (ENSG00000250637, LOC100420534) is a genomic sequence with high similarity to the functional ARHGAP20 gene but does not encode a functional protein. Pseudogenes often arise from gene duplication or retrotransposition events and typically contain disruptive mutations (such as frameshifts or premature stop codons) preventing protein translation or function. While the functional ARHGAP20 gene encodes a regulator of Rho-type GTPases involved in cytoskeletal dynamics and cell signaling, the pseudogene does not contribute to these biological processes and has no known functional or pathological role. It is categorized neither as a receptor, enzyme, nor any protein class but is a non-coding DNA segment located in the human genome[6][3]. Important note: - The functional version of the gene, ARHGAP20, is a Rho GTPase-activating protein involved in the regulation of cytoskeletal organization and signaling; it plays roles in conditions like cancer. However, this entry (ENSG00000250637) is a pseudogene—it is not the functional ARHGAP20 gene[1][6][3]. --- To summarize, ENSG00000250637 is not a druggable protein, does not fit protein classification systems (receptor, enzyme, etc.), and should not be confused with the functional ARHGAP20 gene. For research or therapeutic purposes, always use the functional ARHGAP20 (not the pseudogene) if seeking a legitimate Rho GTPase-activating protein.

Other names

LOC100420534Rho GTPase activating protein 20 (ARHGAP20) pseudogene