Target intelligence / Profile preview

Rho GTPase activating protein 23 pseudogene

Molecular classification: Other (Pseudogene)

Overview

The Rho GTPase activating protein 23 pseudogene (LOC388248) is a non-protein-coding genomic locus classified as a pseudogene, related to the ARHGAP23 gene family[1][4]. Unlike ARHGAP23, which encodes a GTPase-activating protein that negatively regulates Rho GTPases by promoting their inactivation through GTP hydrolysis[5], this pseudogene does not produce a functional protein. While pseudogenes can in some cases exert regulatory effects at the RNA level—such as serving as microRNA sponges or contributing to post-transcriptional regulation[7]—there is currently no direct evidence that ENSG00000260628/LOC388248 possesses such activity. It is not established as a therapeutic target, does not have known interacting drugs, and has no demonstrated involvement in disease as a causal gene. Its principal relevance is as a genomic feature potentially relevant to gene regulatory studies or evolutionary genomics[1][7].

Other names: LOC388248Rho GTPase activating protein 23 pseudogene

Biological functions

Possible post-transcriptional regulation via competing endogenous RNA (ceRNA) or microRNA-decoy activity, inferred by analogy to other pseudogenes like PTENP1 and KRAS1P

Disease associations

Other (No direct disease role confirmed, though pseudogenes like this may contribute to gene regulatory networks and have been implicated as potential modifiers in cancer via ceRNA effects in analogous systems)

Beyond the preview

Go deeper on Rho GTPase activating protein 23 pseudogene.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Rho GTPase activating protein 23 pseudogene.

Explore the full profile