Rho GTPase-activating protein 24 (ARHGAP24)

Rho GTPase-activating protein 24 (ARHGAP24) is an enzyme that negatively regulates the activity of the small GTPases Rac1 and CDC42 through the enhancement of their intrinsic GTPase activity, converting them from the active GTP-bound state to the inactive GDP-bound state[1][3]. By binding to filamin A, ARHGAP24 is targeted to membrane protrusions where it antagonizes Rac1, suppresses lamella formation, and promotes retraction to regulate cell polarity and cytoskeletal dynamics[1][2]. This protein is crucial for normal processes such as cell migration, differentiation, and proliferation, and its dysregulation is implicated in various pathologies including kidney disease (e.g., focal segmental glomerulosclerosis), cancer (tumor suppressor roles in several cancers), and abnormal neural development[2]. It is considered part of the Rho GTPase-activating protein family and acts as a molecular switch in actin cytoskeleton remodeling, influencing cell morphology and function[1][2].

Other names

FILGAPFilGAPRC-GAP72RCGAP72p73p73RhoGAPSarcoma antigen NY-SAR-88Rho GTPase activating protein 24

GTPase activation (catalyzes the inactivation of RAC1 and CDC42 by increasing their GTPase activity, thus switching them to the inactive GDP-bound form)