Rho GTPase-activating protein 27 (ARHGAP27)

Rho GTPase-activating protein 27 (ARHGAP27) is a member of the RhoGAP family of enzymes that negatively regulate Rho-type GTPases by enhancing their intrinsic GTPase activity, promoting the transition from the active GTP-bound form to the inactive GDP-bound form[1][3]. It is involved in essential cellular processes such as clathrin-mediated endocytosis and compartment-specific signal transduction[1][3]. ARHGAP27 demonstrates activity toward Rho family GTPases, including CDC42 and RAC1, and is likely implicated in multiple signaling pathways due to its modular protein domains[2][3]. Disease associations include tumorigenesis and rare metabolic disorders, though its role is not fully characterized[3]. Currently, there are no known drugs that specifically target ARHGAP27, and its direct use as a biomarker or safety concern in therapeutics has not been established in the literature[3].

Other names

CAMGAP1SH3D20SH3P20PP905FLJ43547CIN85-associated multi-domain-containing Rho GTPase-activating protein 1SH3 domain-containing protein 20

Stimulates the GTPase activity of Rho family proteins, converting them from active GTP-bound to inactive GDP-bound states