Rho GTPase-activating protein 32 (ARHGAP32)

Rho GTPase-activating protein 32 (ARHGAP32) is a brain-enriched enzyme that inactivates Rho-family GTPases (particularly RHOA, CDC42, and RAC1), essential regulators of neuronal cytoskeletal dynamics, dendritic spine morphology, and synaptic plasticity. By promoting GTP hydrolysis, ARHGAP32 maintains the balance of neuronal actin remodeling, impacting learning, memory, and activity-dependent synaptic changes. Regulation by microRNA-132 and genetic association with neuropsychiatric traits highlight its role in neuronal function and disease. It is considered a molecular regulator in intracellular signaling pathways and may represent a novel therapeutic target for psychiatric and neurodevelopmental disorders, although no approved drugs directly target ARHGAP32.

Other names

GRITRICSGC-GAPKIAA0712PX-RICSP200RhoGAPP250GAPBrain-specific Rho GTPase-activating proteinGAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkARac GTPase activating proteinMGC1892RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

Inhibition or modulation of ARHGAP32 would alter GTPase activity of RHOA, CDC42, and RAC1, affecting neuronal cytoskeleton and synaptic function. Currently, the primary regulation is post-transcriptional (e.g., by microRNA-132), not small-molecule agents.