Rho GTPase-activating protein 40 (ARHGAP40)

Rho GTPase-activating protein 40 (ARHGAP40) is an enzyme that acts as a GTPase activator for Rho-type GTPases, converting these molecular switches from their active GTP-bound form to their inactive GDP-bound state[3][6]. This process downregulates Rho GTPase signaling pathways, which are essential for various cellular functions such as regulation of actin cytoskeleton dynamics, cell shape, migration, and proliferation[1][2][3]. ARHGAP40 is predicted to localize to the cytoplasm and cytosol, where it is involved in modulating signal transduction and cytoskeletal architecture[3][5]. Its expression is detected in multiple tissues, with prominent RNA expression in squamous epithelia[7]. While ARHGAP40 belongs to the broader family of Rho GTPase-activating proteins—key cellular regulators—its specific functions and disease involvements are less characterized compared to more studied family members. There are no well-documented direct drug interactions, biomarker roles, or safety concerns attributed specifically to ARHGAP40 as of the latest available data.

Other names

C20orf95dJ1100H13.4Rho-type GTPase-activating protein 40