Rho guanine nucleotide exchange factor 28 (ARHGEF28)

Rho guanine nucleotide exchange factor 28 (ARHGEF28) is an enzyme that functions as a guanine nucleotide exchange factor (GEF), specifically activating the small GTPase RHOA and regulating cell signaling pathways downstream of integrins and growth factor receptors[1][2][7][8]. It is involved in neuronal development including axonal branching, synapse formation, dendritic morphogenesis, and also plays a role in focal adhesion formation, cell motility, B-lymphocyte activation, and apoptosis[1][7]. ARHGEF28 is associated with diseases such as amyotrophic lateral sclerosis, frontotemporal dementia, and spondyloepimetaphyseal dysplasia[1][2]. Several alternative names exist for ARHGEF28, reflecting its discovery history and various functional aspects. There is currently no evidence of approved drugs directly targeting this protein or its use as a biomarker for therapy or patient monitoring[1][2][7].

Other names

RGNEFKIAA1998p190-RhoGEFp190RhoGEFRIP2190 kDa guanine nucleotide exchange factorRho interacting protein 2

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