Rho guanine nucleotide exchange factor 37 (ARHGEF37)

Rho guanine nucleotide exchange factor 37 (ARHGEF37) is a protein-coding gene that encodes a guanine nucleotide exchange factor (GEF), which activates Rho family small GTPases by promoting the exchange of GDP for GTP[1][10]. ARHGEF37 is predicted to be active in the cytoplasm and is implicated in signal transduction pathways, including clathrin-mediated endocytosis, where it assists dynamin 2 at late endocytic sites[6][8]. Genetic variants in ARHGEF37 have been associated with rare diseases such as epidermolysis bullosa simplex 1A and thiamine-responsive megaloblastic anemia syndrome[1]. No drugs are currently known to target ARHGEF37 directly, nor are there established biomarker or safety concerns for therapeutic intervention involving this gene.

Other names

ARHGEF37FLJ41603Rho guanine nucleotide exchange factor (GEF) 37