Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Rho guanine nucleotide exchange factor 38 (ARHGEF38)
- Target
- ARHGEF38
- Molecular classification
- Guanine nucleotide exchange factor (GEF), Enzyme, Signaling protein
01
Overview
Rho guanine nucleotide exchange factor 38 (ARHGEF38) is a protein encoded by the ARHGEF38 gene. It is a guanine nucleotide exchange factor (GEF) that is predicted to act as a guanyl-nucleotide releasing factor, activating Rho family GTPases involved in regulating cytoskeletal organization, cell migration, and polarity[1][2][3][7][9]. It is primarily located in the cytoplasm and is implicated in cell signaling pathways such as GPCR downstream signaling and p75 NTR receptor-mediated signaling[1]. ARHGEF38 expression is associated with aggressive tumor characteristics and has been identified as a potential biomarker for prostate cancer prognosis, with higher expression correlating to increased metastasis, higher Gleason scores, and poorer survival rates[4].
- Other names
- ARHGEF38FLJ20184Rho guanine nucleotide exchange factor (GEF) 38ARHGEF38 proteinDNMBP paralog
02
Mechanism of action
Potential modulation of Rho GTPase activity via GEF catalytic function (for any drug targeting this, based on GEF mechanism)
03
Biological functions
Signal transductionActivation of Rho family small GTPasesCell migrationRegulation of cell polarityRegulation of cytoskeletal dynamics
04
Disease associations
Cancer (notably prostate cancer)Cleft lip/palate (association)Tumor cell metastasis
05
Safety considerations
None reported
06
Biomarkers
Tissue expression (protein or mRNA) as a prognostic and diagnostic biomarker for prostate cancer aggressiveness and progression
Beyond the preview
Go deeper on Rho guanine nucleotide exchange factor 38 (ARHGEF38).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Rho guanine nucleotide exchange factor 38 (ARHGEF38).