Rho guanine nucleotide exchange factor TIAM2 (TIAM2)

TIAM2 (Rho guanine nucleotide exchange factor TIAM2) is a guanine nucleotide exchange factor (GEF) that specifically activates Ras-related C3 botulinum substrate 1 (RAC1), a Rho-like small GTPase, by stimulating the exchange of GDP for GTP and shifting RAC1 to its active, GTP-bound state. TIAM2 functions to modulate cell motility, cytoskeletal reorganization, and directional cell movement, and it plays a role in neural cell development and migration. Alternative splicing produces multiple isoforms with distinct biological effects. TIAM2 and its closely related paralog TIAM1 are involved in cancer cell invasion and metastasis. Disease associations include lymphoma and Griscelli syndrome type 3, and abnormal TIAM2 activity is linked to altered cell motility in cancer and potentially neural development disorders.

Other names

TIAM Rac1 associated GEF 2KIAA2016STEFSIF and TIAM1-like exchange factorT-lymphoma invasion and metastasis-inducing protein 2Sif and Tiam1-like exchange factorTIAM-2rho guanine nucleotide exchange factor TIAM2T cell lymphoma invasion and metastasis 2

Inhibition of GEF activity (potential, for experimental inhibitors) Modulation of RAC1 activation (by affecting GDP-GTP exchange)