Rho-related GTP-binding protein RhoE (RND3)

Rho-related GTP-binding protein RhoE (RND3) is a member of the Rnd subfamily within the Rho family of small GTPases, which itself is part of the larger Ras superfamily[1][2]. RND3 uniquely binds GTP but lacks intrinsic GTPase activity, making it constitutively GTP-bound and functionally distinct from most Rho GTPases[1][5]. It plays a critical role in regulating cytoskeletal dynamics, cell shape, polarity, migration, and the assembly of apical and tight junctions in epithelial cells[3][5]. RND3 is implicated in cancer biology, demonstrating context-dependent roles in tumor growth and metastasis; its overexpression or dysregulation has been linked to both tumor-promoting and tumor-suppressing activities, depending on the tissue type and cellular context[4]. As of the latest data, there are no approved drugs targeting RND3 directly, and clinical exploitation as a biomarker or therapeutic target is still investigational.

Other names

RND3ARHERHO8RHOERhoERho8Protein MemBmemBras homolog gene family member ERnd3

Not applicable (no current drugs specifically target RND3); mechanistically, targeting RND3 would likely affect cell signaling and cytoskeletal dynamics