Rho-related GTP-binding protein RhoU (RHOU)

Rho-related GTP-binding protein RhoU (RHOU) is a member of the Rho family of small GTPases, which are pivotal regulators of the actin cytoskeleton, cell morphology, and motility. RHOU interacts with effector proteins to regulate the assembly of focal adhesions and cytoskeleton remodeling during cell migration. It is capable of activating downstream kinases, such as PAK1 and JNK1, and inducing filopodium formation, stress fiber dissolution, and changes in cellular adhesion. While typically regulated by upstream signaling pathways (such as Wnt), RHOU is constitutively active in its GTP-bound form and may play a unique role compared to other Rho family members in cell migration, polarization, and potentially oncogenic processes[3][4][1]. If you need more structured or disease-related annotations (such as interaction with specific drugs or established biomarker status), these are currently not reported for RHOU in available databases and literature.

Other names

ARHUCDC42L1WRCH1SB128DJ646B12.2FLJ10616hG28KfJ646B12.2CDC42-like GTPase 1GTP-binding protein-like 1Rho GTPase-like protein ARHURyu GTPaseWnt-1 responsive Cdc42 homolog 12310026M05RikGTP-binding protein SB128ras homolog gene family member UG28K