Rhomboid domain-containing protein 2 (RHBDD2)

Rhomboid domain-containing protein 2 (RHBDD2) is an integral membrane protein and a member of the rhomboid superfamily, considered to be a rhomboid-like or pseudoprotease due to uncertain or absent protease activity[1][4]. RHBDD2 is mainly localized to the Golgi apparatus and perinuclear regions of various cells, where it is implicated in trafficking and turnover of membrane proteins, potentially influencing secretory and sorting processes via a conserved glycine zipper motif[2]. RHBDD2 is widely expressed, with particular abundance in developing and proliferating tissues, such as the retina and mammary gland[1][2]. Overexpression of RHBDD2 is frequently observed in advanced breast cancers, particularly ER-negative tumors, where it is associated with poor prognosis and increased proliferation[3][4]. Mutations in RHBDD2 have been linked to inherited retinal degenerative disorders (e.g., retinitis pigmentosa)[2]. Current research suggests RHBDD2 modulates signaling pathways related to tumor progression and possibly the unfolded protein response, but no direct drug modulators are in clinical use or late-stage development as of the latest reports[3][4].

Other names

RHBDL7NPD007rhomboid domain-containing protein 2rhomboid, veinlet-like 7RHBDD2