Rhomboid-like protein 1 (RHBDL1)

Rhomboid-like protein 1 is a member of the rhomboid family of intramembrane serine proteases, which are responsible for regulated proteolysis of membrane proteins within the lipid bilayer. RHBDL1 possesses a characteristic topology with multiple transmembrane domains forming a protease ring, allowing it to cleave substrates such as growth factor precursors at specific sites. It is most closely related to secretase-type rhomboid proteases, participating in the release of functional peptides from their membrane anchors and modulating cell signaling cascades, including those relevant in cancer pathogenesis (e.g., trafficking of pro-transforming growth factor alpha). While RHBDL1 is considered a valid molecular target for research in oncology and cell biology, no approved drugs or clinical interventions specifically target this protein to date. Early structural studies have revealed its architectural details, including the arrangement of catalytic residues and transmembrane segments.

Other names

Rhomboid-related protein 1RHBDL1RHBDLRRPRhomboid-like protein 1rhomboid, drosophila, homolog ofveinlet-like 1

Inhibition of RHBDL1 would block regulated cleavage of membrane proteins, potentially altering growth factor or cytokine signaling. Targeting RHBDL1 may modulate cleavage-dependent signaling pathways relevant in cancer.