Rhophilin Rho GTPase binding protein 2 (RHPN2)

Rhophilin Rho GTPase binding protein 2 (RHPN2) is a cytoplasmic effector protein belonging to the rhophilin family that binds both GDP- and GTP-bound RhoA and GTP-bound RhoB[3]. It contains an N-terminal Rho-binding domain, a Bro1-like domain, and a C-terminal PDZ domain[1][2]. RHPN2 plays a key role in actin cytoskeleton organization, regulates stress fiber formation, and is involved in cell migration and invasion, likely acting within Rho GTPase–mediated signaling cascades[2][3]. Overexpression or mutation of RHPN2 is associated with enhanced tumor cell proliferation, migration, and poor prognosis in several types of cancer, particularly lung adenocarcinoma and hepatocellular carcinoma. RHPN2 may upregulate oncogenic pathways (such as c-Myc or Hippo-YAP) and promote mesenchymal transformation; it is under investigation both as a cancer biomarker and as a candidate target for anti-cancer therapy[2][4]. No direct-acting drugs or inhibitors are currently known.

Other names

Rhophilin-276 kDa RhoB effector proteinGTP-Rho-binding protein 2p76RBEP76RBERHOBPrhophilin-2rhophilin-like Rho-GTPase binding protein

Not applicable / none described for direct drug targeting (acts as a RhoA/RhoB effector and mediator of Rho GTPase signaling)