Rhox homeobox family member 1 (RHOXF1)

Rhox homeobox family member 1 (RHOXF1) is a homeobox-containing transcription factor predominantly expressed in human reproductive tissues, including the testis, ovary, epididymis, placenta, and, to a lesser extent, in the brain and fetal tissues[1]. RHOXF1 belongs to the RHOX gene cluster located on the X chromosome, which is selectively expressed in germ cells and is thought to play key roles in stages of spermatogenesis and oogenesis[1]. Functionally, RHOXF1 is localized mainly in the nucleus of developing germ cells, consistent with its role as a transcription factor, although it can also be found in the cytoplasm[2]. RHOXF1 is involved in gene regulation during critical stages of germ cell development; its gene regulatory network appears to interact with related homeobox factors such as RHOXF2/2B[2]. While there is evidence from animal models that homologs of RHOXF1 are important for fertility, the role of RHOXF1 mutations or altered expression in human disease such as infertility remains under investigation[1][2]. No drugs are known to directly target RHOXF1, and it is not currently classified as a therapeutic target, but it and its downstream networks are under consideration as potential diagnostic markers or targets for infertility intervention[2].

Other names

RHOXF1OTEXPEPP1Ovary-, testis- and epididymis-expressed gene proteinPaired-like homeobox protein PEPP-1PEPP subfamily gene 1GS1-421I3.4TCONS_00017087LINC01402