RIB43A domain with coiled-coils 1 (RIBC1)

RIBC1 (RIB43A domain with coiled-coils 1) is a protein encoded by the human RIBC1 gene and is characterized by the presence of a RIB43A domain and predicted coiled-coil structural features[4]. It is homologous to a family of microtubule inner proteins (MIPs) known to localize in the inner lumen of doublet microtubules in cilia and flagella of unicellular organisms and mammals[1][3]. In mouse models, RIBC1, together with RIBC2, contributes to sperm flagellar motility but is not alone critical for male fertility unless both homologs are deleted[1]. The precise function in mammalian or human cells remains to be defined, but its primary association is structural, linked to ciliary and flagellar architecture, and, by extension, potentially to microtubule organization[1][2][3]. There is currently no evidence that RIBC1 serves as a disease biomarker, drug target, or is directly linked to human pathologies.

Other names

RIB43A-like with coiled-coils protein 1FLJ327832610028I09RikRIBC1

None described