Riboflavin-dependent enzyme

Riboflavin-dependent enzymes—commonly called flavoproteins or flavoenzymes—are a broad and functionally diverse class of enzymes that use flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD), both derived from riboflavin (vitamin B2), as essential cofactors[1][3][5]. Through redox-active flavin cofactors, these enzymes catalyze one- or two-electron transfer reactions crucial for cellular energy production, cellular redox balance, mitochondrial function, detoxification, and biosynthetic processes[1][3][4][5]. Members include succinate dehydrogenase and glutathione reductase, supporting roles in the citric acid cycle, respiratory chain, and antioxidant defense[1][4][5]. Defects or deficiencies in riboflavin-dependent enzyme systems are linked to mitochondrial disease, metabolic disorders, increased oxidative stress, and potentially neurodegenerative and cardiovascular disease[4][5]. “Riboflavin-dependent enzyme system” is a class/category, not a single molecular target. For translational or drug development purposes, more specific individual flavoproteins (e.g., glutathione reductase, NADPH oxidase, succinate dehydrogenase) should be specified for structured data. Additional notes: - is_incorrect is true because "Riboflavin-dependent enzyme system" is a descriptive class (system), not a unique molecular entity; it cannot be uniquely mapped to one protein, gene, or therapeutic target (violates specific singular canonical name requirements). - Most entries above refer to the class of all enzymes using riboflavin-derived cofactors, typically called “flavoproteins”[1][5]. For structured data or target-centric drug development, individual enzymes should be specified. - Interacting drugs at the system level are riboflavin/analogs; drugs typically modulate individual enzymes within this system[6]. If you need information for a specific enzymes such as “succinate dehydrogenase (SDH)” or “glutathione reductase (GSR)”, provide the explicit name for targeted details.

Other names

FlavoproteinFlavin-dependent enzymeFlavoenzyme

Electron transfer (cofactors facilitate electron transfer in enzyme catalysis), Redox cycling (glutathione reductase), Direct metabolic modulation