Riboflavin transporter 1 (SLC52A1)

Riboflavin transporter 1 (SLC52A1) is a member of the solute carrier family 52 that functions as a transmembrane transporter for riboflavin (vitamin B2), facilitating its uptake into cells[1][2][3]. SLC52A1 is primarily expressed in the placenta and small intestine and plays a critical role in supplying riboflavin for metabolic processes, especially for mitochondrial oxidative phosphorylation and redox enzyme activity. Genetic deficiency in SLC52A1 causes riboflavin transporter deficiency type 1 (RTD1), a rare neurological disorder characterized by placental dysfunction and sensorimotor neuropathy[5]. SLC52A1 activity regulates cellular senescence by ensuring sufficient riboflavin-dependent mitochondrial function, and acts as a downstream component of the p53 pathway in negative feedback on senescence induction[1][2]. Drugs such as riboflavin supplementation are used therapeutically in transporter-deficient states to restore normal cellular metabolism.

Other names

SLC52A1GPR172BPAR2RFT1PERV-A receptor 2huPAR-2hRFT1FLJ10060GPCR42RFVT1Riboflavin transporter 1Porcine endogenous retrovirus A receptor 2Protein GPR172Briboflavin transporter 1G-protein coupled receptor GPCR42porcine endogenous retrovirus A receptor 2

Uptake and transmembrane transport of riboflavin to supply cofactors for mitochondrial and cellular metabolism[1][2] Drugs targeting SLC52A1 (e.g., riboflavin supplementation) restore or augment cellular riboflavin levels, supporting energy metabolism and preventing neurodegeneration in deficiency states[5]