Target intelligence / Profile preview

Ribonuclease A family member 12 (inactive) (RNASE12)

Target
RNASE12
Molecular classification
Enzyme (Ribonuclease A family, but inactive)
01

Overview

Ribonuclease A family member 12 (RNASE12) is a protein-coding gene located on human chromosome 14. It is classified as part of the ribonuclease A superfamily based on sequence but is predicted to be inactive and does not exhibit ribonuclease enzymatic activity. Some gene ontology predictions suggest it may participate in nucleic acid binding or in defense responses, but there are no established physiological functions or roles in disease, nor are there known interacting drugs or therapeutic applications. RNASE12 is not considered a pharmacological or therapeutic target. It lacks enzymatic function, has no known role in major disease processes, and there are no known drugs targeting it. The gene is also known by multiple aliases, largely reflecting its predicted family or historical/unverified annotations, but "Ribonuclease A family member 12 (inactive)" is the most accurate current descriptor.

Other names
RAI1Probable inactive ribonuclease-like protein 12Ribonuclease, RNase A family, 12 (non-active)Epididymis secretory sperm binding protein Li 85pRibonuclease-like protein 12Ribonuclease A I1HEL-S-85p
02

Biological functions

Predicted nucleic acid bindingPredicted RNA nuclease activityPossible involvement in defense response to Gram-positive bacteriumExperimental evidence suggests it does not exhibit ribonuclease activity
03

Disease associations

Other (no established or direct role in diseases)

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